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1) Mathematical background for modeling of the concentration time relationships for the different routes of administration. 2) Designing dosing regimens by relating plasma concentration of drugs to their pharmacological and toxicological action, 3) Individualization of therapy for patients. 4) Designing therapeutic drug monitoring plans for drugs with narrow therapeutic index or high toxicity.
Fourth year
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Topic Introduction Routes of administration Compartmental PK Non-compartmental PK Non-linear PK Physiological PK Population PK Role of PK in drug development Bioavailability Bioequivalence Statistics of bioequivalence IVIVC Pharmacodynamics
Third year
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Linear compartment models, One-compartment model (IV bolus, infusions, oral administration), Curve stripping exponentials Linear compartment models, Two-compartment model (IV bolus, infusions, oral administration), polyexponential equations - relationship to compartmental models; Multi-compartment models. Multiple dosing, prediction/simulation of single and multiple dose, superposition, dose proportionality. PK/PD variability, special populations, pediatrics, elderly, effect of age, weight, disease on pharmacokinetics; Therapeutic and Clinical PK Applications: Therapeutic Drug Monitoring Nonlinear pharmacokinetic principles, Michaelis-Menten Kinetics, zero-order kinetics, Time Dependent Pharmacokinetics
Third year